Sasmar Conceive Plus - Scientifically Proven supporting fertility and conception

Because Family Is Important

THE INGREDIENTS, PH AND OSMOLARITY

Sasmar Conceive Plus™ is the ONLY sperm friendly lubricant product that contains calcium and magnesium ions. (International patents pending).

Studies Published by ASRM (American Society of Reproductive Medicine)

Sasmar Conceive Plus™ Ingredients list

1. Water: Pure and natural water is used to make the Sasmar Conceive Plus™ water-based lubricant.

2. Sodium Phosphate: Provides buffering capacity to Sasmar Conceive Plus™ and maintains the pH of our product as designed.

3. Sodium and Potassium Chloride: Commonly used salts to provide tonicity and to maintain the osmolarity of Sasmar Conceive Plus™ formula in the physiologic range of 290-423mOsmol/L (see below).

4. Hydroxypropylmethylcellulose: Hydroxypropylmethyl cellulose (hypromellose) is a hydrogel (gelling agent) used commonly in many pharmaceutical products and over-the-counter (OTC) lubricants, including vaginal lubricants, eye lubricants and tear substitutes.
External Link: http://en.wikipedia.org/wiki/Hypromellose.

5. Glycerol: Glycerol is a natural ingredient of human cervical fluid (see clinical studies cited in references 1-4 below). In fact, studies have shown that the amount of glycerol in cervical fluid increases during sexual excitement (reference 2). This increase in glycerol has been postulated to be responsible for the lubricating quality of this fertile cervical fluid and may be biologically relevant during the early phase of reproductive events (reference 3). Sasmar Conceive Plus™ contains small amounts of glycerol in order to better mimic the natural fertile cervical fluids. Click here for a more detailed summary of scientific literature on the effects of glycerol on human reproductive biology.

6. Calcium and Magnesium Ions: Calcium and Magnesium ions are naturally present in all bodily fluids and cells, including cervical fluids (see reference 5 below). Calcium and magnesium are critically important for the viability and function of sperm and eggs. Sasmar Conceive Plus™ is the ONLY formulation that contains these important ingredients.
External Links:
http://en.wikipedia.org/wiki/Calcium_in_biology
http://en.wikipedia.org/wiki/Magnesium_in_biology.

7. Methylparaben: An anti-microbial preservative commonly used in many OTC lubricants and other products to prevent microbial growth.
External Link: http://en.wikipedia.org/wiki/Methylparaben

The pH Range of Conceive Plus™

Studies have shown that the optimal environment for sperm survival and migration in the cervical mucus has a pH within the range of 7.0 to 8.5 (see scientific studies cited in references 6-7 below).

Sasmar Conceive Plus™ is designed to be within the pH range of 7.0-8.5. Typically, the pH of Sasmar Conceive Plus™ formula is close to 7.5.

The Osmolarity of Conceive Plus™

Studies have shown that the sperm survival and migration in the cervical mucus also requires an isotonic environment. Semen is well known for its high osmolarity as compared to blood plasma. There is considerable debate about its exact osmolarity, however various clinical studies have shown it to be within the range of 290-423mOsmol/L (see reference 8 below and the studies cited in that reference). Sasmar Conceive Plus™ is formulated to have an osmolarity in the same range.

Typically the osmolarity of the Sasmar Conceive Plus™ formulation is close to 357mOsmol/L.

The Conceive Plus™ Formula Does NOT Contain:

1. EDTA: A metal chelator that removes calcium and magnesium ions from the solution. EDTA is also used in contraceptive lubricants.
External Link: http://en.wikipedia.org/wiki/EDTA
2. Any larch plant bark derivative, such as Arabinogalactan: Clearly not natural to human body.
3. NaOH: Very toxic base.
External Link: http://en.wikipedia.org/wiki/Naoh
4. Surfactants: Surfactants (such as nonoxynol-9) are spermicidal and are typically used in contraceptive lubricants to reduce chances of conception and pregnancy. External Link: http://en.wikipedia.org/wiki/Nonoxynol-9. Pluronic, present in other lubricants, is also a known surfactant. External Link: http://en.wikipedia.org/wiki/Pluronic.
5. Acidic polymers: Acidic polymers, such as Carbomer (which are polymers of acrylic acid), are one of the key ingredients of spermicidal lubricants, such a BufferGel (see references 9-10 below) that reduce the chance of conception and pregnancy.

References
1. Volatile constituents of human vaginal secretions. Authors: George Huggins and George Preti (University of Pennsylvania School of Medicine). Am J Obstet Gynecol, 1976 Sep 1;126(1):129-36.
2. Alterations in the organic compounds of vaginal secretions caused by sexual arousal. Authors: George Preti, George Huggins and Geoffrey Silverberg (University of Pennsylvania School of Medicine). Fertil Steril 1979;32:47–54.
3. Vaginal odors and secretions. Authors: George Huggins and George Preti (University of Pennsylvania School of Medicine). Clinical Obstetrics and Gynecology, 1981; 24; 355-377.
4. A vaginal fluid simulant. Authors: Derek Owen and David Katz (Duke University). Contraception, 1999 Feb;59(2):91-5.
5. The elemental composition of the environments of the gametes and preimplantation embryo during initiation of pregnancy. Authors: R Borland, S. Hazra, J. Biggers and C. Lechene (Harvard Medical School). Biology of Reproduction, 1977; 16; 147-57.
6. WHO Laboratory Manual for the examination of human Semen and Sperm-Cervical mucus interaction (1999), 4th Edition. Cambridge University Press, Cambridge, UK.
7. Practical Laboratory Andrology (1994). Author: David Mortimer. Oxford University Press, NY.
8. A review of the physical and chemical properties of human semen and the formulation of a semen simulant. Authors: Derek Owen and David Katz (Duke University). J Androl. 2005 Jul-Aug;26(4):459-69.
9. Comparative in vitro spermicidal activity of chelating agents and synergistic effect with nonoxynol-9 on human sperm functionality. Authors: Chi-Hyun Lee, Robert Bagdon and Yie W. Chien (State University of New Jersey, College of Pharmacy). Journal of pharmaceutical sciences, 1996, 85; 91-95.
10. The rate at which human sperm are immobilized and killed by mild acidity. Authors: Stuart Olmsted, Norman Dubin, Richard Cone and Thomas Moench (Johns-Hopkins University and ReProtect LLC). Fertil Steril. 2000 Apr;73(4):687-93.