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Getting Pregnant Tips, World News January 4, 2013

Frozen sperm as good as fresh for IVF treatment

A recent study published in PLOS ONE finds that frozen sperm retrieved via testicular biopsy is as good as fresh sperm in leading to a successful pregnancy through IVF. The finding should make it easier to organize IVF procedures and increase options for infertile couples.

IVF (in vitro fertilization) is a technique that helps couples with fertility problems to have a baby. During the procedure, an egg is removed from the woman’s ovaries, fertilized in a lab dish with sperm from the man, and the fertilized egg or embryo is then placed in the woman’s womb to grow and develop.

If the man has a low sperm count or no sperm in his semen at all – for example because of an inherited disorder or as a result of cancer – then viable sperm has to be retrieved directly from the testicle with a biopsy. This is then either used straight away as fresh sperm, or frozen for future use.

The procedure is called intracytoplasmic sperm injection (ICSI) and involves injecting a single sperm into the egg, instead of adding the sperm to the egg in a lab dish.

If fresh sperm is used in the ICSI procedure, then events concerning both partners have to be synchronized precisely to maximize the chances of a successful pregnancy.

But if frozen sperm can be used, then this simplifies the overall IVF process considerably, from a number of angles. For instance, from the timing angle, the man can give his sperm in advance, and from the location angle, the biopsy may not have to take place at the same clinic or surgery as the one the woman must attend.

Kenan Omurtag, first study author and assistant professor of obstetrics and gynecology at Washington University School of Medicine in St. Louis, told the press: “The convenience and ease of being able to use frozen sperm taken by biopsy in ICSI offers many advantages over fresh sperm.”

When the procedure uses fresh sperm, the man has to undergo the testicle biopsy either the same day or the day before the egg is retrieved from the woman, and this may not be convenient for them.

If frozen sperm is used, then the man can have the biopsy, and if sperm is found, it can be frozen for later use. Then, at a time convenient for the couple, the woman has her eggs harvested, and the rest of the ICSI, where the sperm is injected into the egg, can take place.

The issue of convenience is important because it is not just a matter of the woman dropping into the clinic when she happens to feel like it. Before her eggs can be harvested, she has to have hormone injections every day for 7 to 10 days to stimulate her ovaries. And when the eggs are ready to be harvested, the doctor finds them with an ultrasound scanner, and removes them with a very thin, hollow needle.

For their study, Omurtag and colleagues analyzed 15 years of data from the Washington University Infertility and Reproductive Medicine Center.

Of 136 men who underwent ICSI, 84% of the procedures used frozen sperm and the rest used fresh sperm.

The researchers found that frozen sperm performed as well as fresh sperm in ICSI in terms of pregnancy success rate, despite there being a statistically significant difference in fertilization rate (frozen sperm 62%, fresh sperm 47%).

They also found that the type of center or clinic where the sperm was taken and its distance to the IVF lab also made no difference to pregnancy success rates.

The participants in this study underwent their testicular biopsies either in an operating room next to the IVF lab, an operating room in another building a mile from the IVF lab, or an ambulatory center 15 mile from the IVF lab.

Co-author and professor of obstetrics and gynecology Randall Odem says: “This study demonstrates that using frozen sperm taken by biopsy works as well for most patients in what matters most – pregnancy rates.”

Researchers in Belgium recently showed it is also possible to develop a low-cost IVF procedure that could perform one treatment cycle for just over $250, making it accessible to many people around the world who cannot afford the conventional method, which in the US costs around $12,400 per cycle.

Written by Catharine Paddock PhD ( http://www.medicalnewstoday.com/)

 


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Social Media, World News April 20, 2012

What is Conceive Plus Fertility Lubricant?

 

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World News November 29, 2009

ASRM publishes Conceive Plus clinical data

ASRM publishes Conceive Plus clinical data

We are proud of the many studies we have done to confirm the unique nature Conceive Plus. In October 2009 our studies were presented at the 2009 Annual Meeting of the American Society for Reproductive Medicine.

Click to view the published studies

Conceive Plus® was cleared safe for use by couples trying-to-conceive by the Food and Drug Administration (FDA) on November 7 2013 under 510(k): K131355. Conceive Plus® is compatible with human sperm, oocytes and embryos and safe for use by trying to conceive couples.

Product code: PEB (lubricant, personal, gamete, fertilization, and embryo compatible) Class II (21 CFR 884.5300)

PREGNANCY TIPS TO HELP YOU CONCEIVE

The time to start working toward a healthy pregnancy is before you conceive. If you are trying to get pregnant our pregnancy tips are good start to get your body ready for conception.  Read more here

MORE ABOUT CONCEIVE PLUS

If you have just started trying to get pregnant or have been trying for a while, Conceive Plus® can help increase your chances of conception naturally! Recommended by doctors, pharmacists and fertility clinics in more than 60 countries, this is the fertility friendly lubricant approved by the FDA and a prescription is not required.


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In the Media, World News May 30, 2009

Pre-Seed Blog attacks Conceive Plus, afraid of the competition?

30 May 2009, Brussels: Dr Joanna Ellington, the inventor of Pre-Seed, sperm-friendly intimate moisturizer, made statements on the blog of her own invention http://www.preseed.com/blog Her latest posting attacks Sasmar Conceive Plus, a conception product which directly competes with Pre-seed in markets around the world. Dr Ellington, claims ‘’Conceive Plus has an osmolality over 400 mOsmo/kg which is a level that is unsafe for sperm”’

CEO of Sasmar, an Australian Bio-tech company, John-Michael Mancini said “Dr Ellington’s comment is false and misleading”. Sasmar Conceive PlusTM has been formulated by scientists and experts from respected university hospitals in the USA that both pH and osmolality are at levels which are safe for sperm with every batch subjected to testing before release”.

The World Health Organisation has reported that the optimal condition for sperm survival and migration in the cervical mucus requires a pH in the range of 7.0 to 8.5 and an isotonic solution. The terms “osmolality” and “tonicity”, should not be confused. It is well known that a solution can be hyperosmotic and isotonic at the same time. Therefore, it is more important to experimentally determine the efficacy of lubricant solutions on sperm viability and motility, and rely on that data rather than merely determining parameters such as osmolality and using osmolality measurements to hypothesize whether a particular lubricant may or may not do harm to sperm.

Mr Mancini said “It is a disappointing that Dr Ellington feels the need to attack her competition in this way, we believe competition and choice is healthy and that it is important to provide accurate information to enable consumers to make informed decisions about their health”.

Among many published scientific reports, including a widely cited study by Anderson et al. (“The effects of coital lubricants on sperm motility in vitro”, published in Human Reproduction (1998), 3351-56), comparing measured osmolality of various lubricant solutions and the effect of each of these lubricant solutions on human sperm motility, shows that osmolality alone cannot be the only parameters used to evaluate and determine if a solution is harmful or contraindicated to sperm viability.

Sasmar manufactures a variety of personal lubricants including the Conceive Plus product that is formulated to assist conception and covered by pending international patents. Mancini said “we have been producing premium lubricants for the global market for many years, and Conceive Plus is an extension of the Sasmar brand, now available in many countries around the world, including the USA”.

The posting by Dr Ellington, a Doctor of Veterinary Medicine, is closed for comments.


Trying To Get Pregnant?... Conceive Plus is the ONLY fertility-friendly lubricant that contains Calcium and Magnesium ions essential for the conception process. Find out how Conceive Plus can help you get pregnant, naturally!.... LEARN MORE 
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