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ovulation symptoms

Getting Pregnant Tips, World News December 23, 2013

New Discovery Offers Hope for Infertile Women

Chinese scientists have discovered a protein complex which could help women who suffer from infertility.

Scientists have discovered that cullin-ring finger ligse-4 (CRL4) complex is crucial in maintaining female fertility. For the first time its molecular mechanism can be revealed.

A paper on CRL4 complex and how it works was published in U.S.-based Science Magazine on Friday Beijing time.

Fan Hengyu, research group leader from Zhejiang University, said the discovery has revealed how CRL4 complex works in sustaining fertility and postponing the menopause. This can increase the length of the reproductive period.

A baby girl has 100,000 follicles at birth, which are dormant. From the age puberty parts of the follicles begin to grow every month and mature into eggs that are released during ovulation each month, Fan explained.

“During the course of her lifetime, a woman will ovulate only around 300 to 400 mature eggs, and the end of ovulation means the beginning of the menopause,” said Fan.

For those with Premature Ovarian Insufficiency (POI), characterized by entering the menopause early before the age of 40, getting pregnant remains a dream as there is no treatment.

Specific oocyte genes are essential for follicles and female fertility, the paper said, but the mechanism that regulates the gene expression was poorly understood.

In a laboratory experiment, the scientists deleted the CRL4 complex from a mouse through gene knockout techniques. Showing no abnormality, the mouse was later diagnosed to be infertile. It had symptoms of rapid oocyte loss, POI and fewer fertility maintaining genes.

Further research has revealed how the CRL4 complex works.

“It activates proteins that are involved in fertility to help regulate the expression of genes, and make sure gene reprogramming for fertility is correct,” according to Yu Chao, the paper’s first author.

According to Yu, a woman will enter the menopause earlier without the existence of CRL4 complex, but this may not be the only reason.

Science Magazine has said it is a groundbreaking discovery, as it illustrates the importance of CRL4 complex and provides a possible answer to the cause of infertility.

Fan Hengyu said further studies will be done on females lacking the CRL4 complex.

Through intervening the gene expression women can avoid POI and delay the menopause, which will be a direction for future research, Fan said.

“It offers hope, especially at a time when the country has lifted the ban on having a second baby,” Fan added.

[Source: Xinhua]

Social Media, Success Stories August 1, 2012

BFP! After 2 Miscarriages in a Row and About to Start IVF…

Conceive Plus user testimonial

Posted on Mon, 07/30/2012 – 11:23
Hi, I am 36 and my fiancée is 37. I have a very regular cycle. We started TTC in November 2011 and fell pregnant in December 2011. Unfortunately found our baby had no heartbeat at 9 weeks, had a D&C. Was absolutely gutted but fell pregnant again 4 months later only to start bleeding at 8 weeks – my OB found NOTHING on my scan and suspected an Ectopic.

Went in for an emergency D&C and Laparoscopy and thankfully it was not in my tubes – she couldn’t find it, which meant it, was classified as an “unknown location”. I felt something was wrong at the 6th week mark of this pregnancy as I started spotting and I had ZERO symptoms – sure enough…

5-6 months down the track we were referred to a Fertility Specialist and had all our tests done. My tests came back all normal but DH’s sperm morphology was only 2% (motility and count were normal) which is probably why we weren’t having any success. So, for the past 11 weeks he has been leading a healthier lifestyle and taking lots of vitamins!! We were all booked in to start IVF in 4 weeks time but to our surprise got our BFP yesterday morning!!! We are very excited but also very very nervous.

Here is what we did different which I think helped us achieve our BFP:

* Ovulated on CD 17 – BD 15, 16 and 17 – previous months we just BD’d every 2nd day from CD 10-18;
* Used Ovulation Kit and took my BBT, which I did every month anyway;
* used Conceive Plus (pre-filled applicators);
* DH has been on menevit, zinc, vitamin C for past 3 months (and cutting back on alcohol);

And what I think really helped was I had a HSG done 6 weeks ago. My tubes were both clear but it must have just given them a really good flush out. I would do this again. I am just praying everyday that this one sticks. It has to be my turn this time! I wish all you ladies TTC the very best of luck. It can be a very tough and emotional rollercoaster but what ever happens with this one, I am prepared for anything that comes my way. It is totally out of my control anyway. I have already started having symptoms like nausea and my test line came back faster and darker than the control line.. (that hasn’t happened before :)) So feeling very hopeful.

Baby dust to you all. xxx
(as posted on http://www.twoweekwait.com/node/5083)